Cover Picture: Single‐Cell Imaging of m 6 A Modified RNA Using m 6 A‐Specific In Situ Hybridization Mediated Proximity Ligation Assay (m 6 AISH‐PLA) (Angew. Chem. Int. Ed. 42/2021)
نویسندگان
چکیده
N6-methyladenosine (m6A)-modified RNA analysis is limited at the bulk-population level, thus not giving access to spatiotemporal and cell-to-cell variability information. In their Communication on page 22646, Jinghong Li et al. propose a powerful in situ imaging method, termed m6A-specific hybridization mediated proximity ligation assay (m6AISH-PLA), that enables identification of m6A modifications specific location RNAs with single-cell single-molecule resolution.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/anie.202110138